The Effect of Water Physical Exercise Program in Thermal Water and Hydropinotherapy on Cardiovascular Health

Starting soon · Not applicable

Conditions studied: Cardiovascular (CV) Risk

In brief

The goal of this randomized four-arm clinical trial is to determine the effect of 16-week water physical exercise program in thermal water and hydroponotherapy on lipide profile in middle-aged and elderly people, with controlled health conditions. Participants will be randomizate into four arms: * Arm I: Control * Arm II: Water Physical Exercise Program (WPEP) in thermal water * Arm III: Hydropinotherapy with thermal water combined with bay leaf (L. nobilis) * Arm IV: WPEP in thermal water and hydropinotherapy with thermal water combined with bay leaf (L. nobilis) Primary outcome: 1. Lipid profile (cholesterol total, low-density lipoprotein cholesterol (c-LDL), high-density lipoprotein cholesterol (c-HDL), triglycerides) Secondary parameters: 2. Inflammatory biomarkers: interleukin-6 (IL-6), C-reactive protein (CRP) 3. Glucose metabolisc: fasting plasma glucose, insulin, Hemoglobin A1c (HbA1c) 4. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, creatinine. 5. Anthropometric and clinical variables: weight, waist to hip ratio, body composition and bone mineral density 6. Systolic and diastolic blood pressure 7. Physical function 8. Lifestyle parameters: sleep quality, quality of life and eating habits

Key facts

Study ID

NCT07403305

Run by

Instituto Politécnico de Bragança

People needed

80

Starts

2026-01-19

Expected to finish

2026-10-31

Last updated by the study team

2026-02-11

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men or women
• Age: >45 years
• Written informed consent prior to participation
• Physical condition suitable for participating in physical exercise activities
• Controlled health conditions

You may not qualify if…

• History of chronic or severe diseases that may affect study outcomes or limit study participation, such as:
• Decompensated cardiovascular disease, renal insufficiency, or severe liver disease
• Conditions preventing the ability in physical activity (e.g., severe respiratory issues, reduced mobility, severe arthritis)
• Severe psychiatric or cognitive disorders that could affect comprehension or adherence to the study
• Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or corticosteroids
• Pregnancy or lactation
• Less than 80% attendance at the 16-week aquatic exercise program

Full record on ClinicalTrials.gov

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