Stimulation of External Carotid Artery Circulation

Recruiting now · Not applicable

Conditions studied: Migraine

In brief

This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches. The goal of the study is to determine whether this approach could improve headache symptoms and overall outcomes for people with migraines.

Key facts

Study ID

NCT07402954

Run by

The University of Texas Medical Branch, Galveston

People needed

12

Starts

2026-01-16

Expected to finish

2027-08-01

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18
• Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion.
• Subject has provided informed consent.

You may not qualify if…

• Known allergies to lidocaine
• Seizure disorder, history of seizures, or increased seizure susceptibility
• Intracranial vascular malformations or dural AVF
• Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk
• Previous MMA intervention or craniotomy that could result in MMA occlusion
• Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator)
• Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI)
• Severe autonomic dysfunction
• Active systemic infection
• Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent)

Where it is running

• University of Texas Medical Branch — Galveston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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