Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma
Starting soon · Phase 3
Conditions studied: Oral Cancer, Oropharyngeal Cancer
In brief
The objective of this study is to evaluate the efficacy of neoadjuvant stereotactic body radiation therapy (SBRT) in combination with chemotherapy and immunotherapy, prior to radical surgery, in enhancing the 2-year event-free survival rate and overall survival rate in patients diagnosed with locally advanced oral or HPV-unrelated oropharyngeal cancer.
Key facts
- Study ID
- NCT07402538
- Run by
- Sun Yat-sen University
- People needed
- 184
- Starts
- 2026-02-24
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-02-11
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Patients with concurrent other malignant tumors
- Patients with known or suspected autoimmune diseases, including dementia and epilepsy.
- Patients with severe mental disorders at the same time
- Patients with necrotic lesions who are assessed by the investigator as having a risk of massive hemorrhage
- Patients with severe heart disease or pulmonary dysfunction, and those with cardiac or pulmonary function grade ≤ 3 (grade 3 inclusive)
- Patients with laboratory test results that do not meet the relevant criteria within 7 days prior to enrollment
- Received systemic or local glucocorticoid therapy within 4 weeks prior to enrollment
- Patients with comorbidities requiring long-term treatment with immunosuppressive drugs, or requiring systemic or local administration of corticosteroids at immunosuppressive doses.
- Patients with active tuberculosis (TB), who are receiving anti-tuberculosis treatment or have received anti-tuberculosis treatment within 1 year prior to screening.
- A history of prior use of anti-Tislelizumab, anti-PD-L1 antibodies, anti-PD-L2 antibodies, or anti-CTLA-4 antibodies (or any other antibodies targeting T-cell co-stimulation or checkpoint pathways).
- Subjects with any active autoimmune diseases or a history of autoimmune diseases (including but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, nephritis, hyperthyroidism, hypothyroidism); subjects with vitiligo or those whose childhood asthma has been completely relieved and who do not require any intervention in adulthood are eligible for enrollment; those with asthma requiring medical intervention with bronchodilators are not eligible for enrollment.
- HIV-positive subjects
- Positive for HBsAg with concurrent positive HBV DNA copy number (quantitative test ≥ 1000 cps/ml); positive for chronic hepatitis C on blood screening (HCV antibody positive)
- Received any anti-infective vaccines (such as influenza vaccine, varicella vaccine, etc.) within 4 weeks prior to enrollment
- Pregnant women with positive pregnancy test results among females of childbearing potential and lactating women.
Where it is running
- Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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