Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage

Recruiting now · Phase 4

Conditions studied: Postpartum Hemorrhage, Twin Pregnancy

In brief

The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems. In this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery. The main questions this study aims to answer are: * Does giving carbetocin after delivery lower blood loss compared with standard oxytocin treatment? * Is carbetocin safe and practical to use in twin deliveries? Researchers will compare carbetocin to standard oxytocin treatment to see which approach better prevents bleeding after twin vaginal or cesarean delivery. Participants will: * Be randomly assigned to receive either carbetocin or standard oxytocin after the second twin is delivered * Have blood tests before delivery and on the day after delivery * Be followed during their hospital stay and for up to six weeks after delivery for safety outcomes

Key facts

Study ID

NCT07401524

Run by

Sheba Medical Center

People needed

120

Starts

2026-05-05

Expected to finish

2028-12-01

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant individuals aged ≥18 years
• Twin pregnancies
• Gestational age ≥23 weeks

You may not qualify if…

• Known hypersensitivity or contraindication to carbetocin
• Higher-order multiple gestation (triplets or more)
• Maternal age <18 years
• Known placenta accreta spectrum
• Known bleeding disorder
• Intrauterine fetal death of one or more fetuses
• Hyponatremia precluding oxytocin use
• Planned delivery at a non-participating hospital

Where it is running

• Sheba Medical Center — Ramat Gan, Israel (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.