A Multimodal AI Agent for Ophthalmic Clinical Decision Support

Starting soon · Not applicable

Conditions studied: Ophthalmology, Large Language Models, AI Agent, Eye Disease, Retinal Disease

In brief

This study is a multicenter randomized controlled trial evaluating the effectiveness and safety of EyeAgent, a multimodal artificial intelligence (AI) agent designed to assist ophthalmologists in clinical decision-making. Participants will be recruited from ophthalmology clinics and hospitals in Hong Kong and mainland China. The AI agent acts as a digital co-pilot, analyzing patient images and clinical history to provide diagnostic and management recommendations. The trial aims to determine whether the use of the AI agent improves diagnostic accuracy, treatment decision-making performance, report generation, workflow efficiency, and user satisfaction compared to standard clinical practice.

Key facts

Study ID

NCT07401459

Run by

The Hong Kong Polytechnic University

People needed

300

Starts

2026-03-01

Expected to finish

2026-12-31

Last updated by the study team

2026-02-23

Who can join

Age: 6 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Outpatient participants aged 6 to 75 years.
• Participants who undergo ophthalmic examinations for medical purposes during the study period.
• Participants who can produce clear ophthalmic images in both eyes.
• Agree to participate in this study with written informed consent:
• Participants aged 18 years or older provide their own consent.
• Participants aged 6-17 years require consent from a parent or legal guardian.

You may not qualify if…

• Participants who are reluctant to participate in this study.
• Participants presenting with acute or emergency ocular conditions requiring immediate intervention.
• Participants with poor quality of ophthalmic images, including blurriness, artifacts, underexposure, or overexposure.
• Other unsuitable reasons determined by the evaluators.

Where it is running

• The Hong Kong Polytechnic University — Hong Kong, China

Full record on ClinicalTrials.gov

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