The Safety and Efficacy of Direct SLT in Pseudoexfoliation Glaucoma

Starting soon · Not applicable

Conditions studied: Pseudoexfoliation Glaucoma

In brief

Prospective, multi-center, single arm, interventional study evaluating DSLT in patients with pseudoexfoliative glaucoma.

Key facts

Study ID

NCT07401290

Run by

Vance Thompson Vision

People needed

40

Starts

2026-03-01

Expected to finish

2028-03-01

Last updated by the study team

2026-02-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients diagnosed with pseudoexfoliation glaucoma (PXFG), with optic neuropathy consistent with glaucomatous damage of any severity
• Open iridocorneal angle by gonioscopy, defined as a Shafer Grade II or greater
• Treatment naive, or washed out IOP ranging from ≥18-35 mmHg
• Able to complete medication washout safely and all follow-up visits
• Participants must have a best correct visual acuity of 20/40 or better in the study eye(s), be able to undertake a reliable Humphrey visual field (HVF) (defined as fixation losses, false positives and false negatives less than 33%), and must have field loss no worse than -20 dB in treatment eye

You may not qualify if…

• Any contraindication to SLT or unable to have DSLT
• Angle closure glaucoma or any other types of glaucoma other than PXFG
• Prior incisional glaucoma surgery or glaucoma-related procedures in the study eye
• Any prior refractive surgery
• H/o LPI within last 6 months
• A history of any significant cataract required during study duration or cataract surgery in the last 6 months
• Prior laser trabeculoplasty (ALT/SLT)
• History of ocular inflammation and infection
• Patients who are pregnant or have any clinically relevant systemic disease that may prevent them from reliably completing follow-up visits
• Vulnerable populations that cannot provide proper informed consent will not be enrolled, such as children, prisoners, handicapped, or mentally disabled persons, or economically or educationally disadvantaged persons

Where it is running

• Vance Thompson Vision — Alexandria, Minnesota, United States
• Vance Thompson Vision — Omaha, Nebraska, United States
• Vance Thompson Vision — Fargo, North Dakota, United States

Full record on ClinicalTrials.gov

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