Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery

Recruiting now · Phase 4

Conditions studied: Perineal Injury, Pain Vulva, Perineum; Injury

In brief

The purpose of this research is to determine if using perineal ice packs, medicated witch-hazel pads (MAJOR® Medi-Pads), and topical benzocaine spray (Dermoplast®) helps reduce perineal pain after perineorrhaphy and/or posterior colporrhaphy surgery.

Key facts

Study ID

NCT07401134

Run by

University of Miami

People needed

70

Starts

2026-02-18

Expected to finish

2027-02-01

Last updated by the study team

2026-03-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women ≥ 18 years of age
• Undergoing perineorrhaphy and/or posterior colporrhaphy (rectocele repair/posterior repair) as part of their planned vaginal pelvic reconstructive surgery
• Physically able to apply medicated witch-hazel pads (MAJOR® Medi-Pads) and administer topical benzocaine spray (Dermoplast®) to the perineal area
• Able to understand and willing to provide informed consent

You may not qualify if…

• Known allergy or hypersensitivity to any of the study products or components, including witch hazel, benzocaine, aloe, or other product ingredients
• Minors
• Presence of an indwelling catheter expected to remain in place for ≥7 days postoperatively
• History of chronic pelvic pain syndromes that may confound postoperative pain assessment, including interstitial cystitis/bladder pain syndrome (IC/BPS), endometriosis, pudendal neuralgia, or vulvodynia
• Chronic use (> 3 weeks of continuous use) of opioid pain medication
• Presence of vulvar dermatoses such as lichen sclerosus, lichen planus, or lichen simplex chronicus
• Currently pregnant or breastfeeding
• Anticipated inability to complete postoperative follow-up, including physical or cognitive limitations that would impede self-care or completion of study diaries
• Inability or unwillingness to provide informed consent or comply with study procedures

Where it is running

• University of Miami Hospitals and Clinics — Miami, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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