Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy

Starting soon · Phase 4

Conditions studied: Postoperative Pain, Shoulder Pain

In brief

Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after surgery is well established. However, there have been no studies on sprayed bupivacaine over the diaphragm to reduce shoulder pain in laparoscopic surgery. The purpose of the study is to evaluate if sprayed infra-diaphragmatic bupivacaine compared to placebo (saline) will improve postoperative shoulder pain in patients undergoing benign laparoscopic gynecologic surgery. The entire study will be conducted at Cedar Sinai Medical Center.

Key facts

Study ID

NCT07400146

Run by

Cedars-Sinai Medical Center

People needed

100

Starts

2026-02-01

Expected to finish

2026-08-01

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Provide a signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• 8 years of age or older
• Undergoing laparoscopic surgery at Cedars-Sinai Medical Center with a surgeon in the Minimally Invasive Gynecologic Surgery division.

You may not qualify if…

• Pregnancy
• Urgent/non-scheduled surgery
• Scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure)
• Baseline shoulder pain
• Baseline opioid use
• Baseline of chronic pain syndrome
• Conversion to open surgery
• Allergy or intolerance to bupivacaine, lidocaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen
• Planned post-operative admission

Where it is running

• Cedars Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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