AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Starting soon · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight, Diabetes Mellitus, Type 2
In brief
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. Participant will receive 2 injections every week: an active medicine and a placebo, both taken as injections under the skin once a week. The placebo is a treatment with no active medicine in it and will be given to all participants. In addition to placebo, participants will receive either of the active medicine NNC0487-0111 (the treatment being tested) or Semaglutide (an approved and commonly prescribed treatment used as comparator). Which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07400107
- Run by
- Novo Nordisk A/S
- People needed
- 1000
- Starts
- 2026-05-20
- Expected to finish
- 2029-01-26
- Last updated by the study team
- 2026-03-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Optimal Research Sites — Orange City, Florida, United States
- Encore Medical Research of Weston — Weston, Florida, United States
- Endocrine Research Solutions, Inc — Roswell, Georgia, United States
- Elite Clinical Trials — Blackfoot, Idaho, United States
- Endo And Metab Cons — Rockville, Maryland, United States
- Arcturus Healthcare, PLC. — Troy, Michigan, United States
- Velocity Clin Res, Dallas — Dallas, Texas, United States
- Consano Clinical Research, LLC — Shavano Park, Texas, United States
- Selma Medical Associates — Winchester, Virginia, United States
- Centro de Investigaciones Metabólicas — Capital Federal, Buenos Aires, Argentina
- Centro Médico CIMEL — Lanús Este, Buenos Aires, Argentina
- Centro Médico Privado San Vicente Diabetes — Córdoba, Argentina
- Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda. — Porto Alegre, Rio Grande do Sul, Brazil
- i9 Pesquisas Clínicas — Campinas, São Paulo, Brazil
- CPQuali Pesquisa Clínica Ltda — São Paulo, São Paulo, Brazil
- BR Trials - Ensaios Clínicos e Consultoria Ltda. — São Paulo, São Paulo, Brazil
- Dr. Tatyana Metalova - AIPSMCE EOOD — Gotse Delchev, Bulgaria
- Medical centre Zdrave 1 OOD — Kozloduy, Bulgaria
- UMHAT Pulmed OOD - Pazardzhik, Department of Internal Diseases — Pazardzhik, Bulgaria
- MHAT Heart and Brain EAD - Pleven, Endocrinology and Metabolic Diseases — Pleven, Bulgaria
- DCC I- Pleven EOOD Endocrinology — Pleven, Bulgaria
- MHAT Knyaginya Klementina - Sofia EAD — Sofia, Bulgaria
- MHAT Sveta Sofia EOOD, Department of Endocrinology and Metabolic diseases — Sofia, Bulgaria
- Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology — Sofia, Bulgaria
- Encore Medical Research LLC — Hollywood, Florida, United States
Full record on ClinicalTrials.gov
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