Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation

Starting soon · Not applicable

Conditions studied: Postoperative Delirium, Cerebral Oxygen Saturation, Postoperative Cognitive Dysfunction (POCD)

In brief

This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium and cognitive dysfunction), length of stay in the intensive care unit, and the incidence of postoperative pain, nausea, vomiting, and pruritus in patients undergoing lung lobectomy or segmentectomy using a closed (video-assisted) method (VATS - video-assisted thoracoscopic surgery), in whom one-lung ventilation is applied. The aim of this study is to evaluate the effects of ibuprofen on cerebral oxygenation, postoperative cognitive changes, and delirium in patients undergoing one-lung ventilation.

Key facts

Study ID

NCT07399184

Run by

Ondokuz Mayıs University

People needed

54

Starts

2026-02-15

Expected to finish

2026-09-01

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18-75 years
• American Society of Anesthesiologists (ASA) Physical Status Classification System I-III
• Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation
• New York Heart Association (NYHA) class I-II
• Patients who have been informed about the study and have provided written informed consent will be included.

You may not qualify if…

• Patients younger than 18 years or older than 75 years
• History of alcohol or substance abuse
• Patients with chronic NSAID use and/or NSAID use within the last 30 days, or NSAID allergy
• Allergy to other drugs used in the study (e.g., bupivacaine)
• ASA Physical Status IV-V
• Severe hearing, visual, or speech impairment
• Dementia, Alzheimer's disease, or psychiatric disorders (psychosis, bipolar disorder, schizophrenia)
• History of previous head trauma
• Chronic liver disease
• Pregnancy
• History of cerebrovascular disease
• Moderate-to-severe chronic obstructive pulmonary disease (COPD) (predicted FEV₁ <50%)
• GFR <60 mL/min/1.73 m²
• Patients who do not provide written informed consent
• Conditions that may cause inaccurate cerebral oximetry readings (subdural and/or extracranial hematoma, intracranial arteriovenous shunts, hyperbilirubinemia)
• Patients undergoing emergency surgery
• Patients in whom surgery is initiated as thoracotomy or converted to thoracotomy
• Patients unable to complete the preoperative MMSE (total score ≤24) will be excluded.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.