Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo

Recruiting now · Early Phase 1

Conditions studied: Vitiligo

In brief

The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are: * How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid? * What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid? * What skin problems do participants have when treated with FU with microneedling and steroid? Researchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches. Participants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks. For group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks. Vitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.

Key facts

Study ID

NCT07398807

Run by

Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan

People needed

40

Starts

2025-08-08

Expected to finish

2026-02-01

Last updated by the study team

2026-02-17

Who can join

Age: 4 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients willing to participate in the study
• Patients of age group of 05 -70 years.
• Vitiligo involving less than or equal to 10% body surface area.

You may not qualify if…

• Patients using or have used other treatments for vitiligo
• Pregnant women or lactating women
• Patients with unstable vitiligo
• Patients on immunosuppressant medications due to other diseases
• Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy
• Patient having history of keloids or hypertrophic scars
• Patients with history of hypersensitivity to either of the drugs

Where it is running

• CMH Bahawalpur — Chak Four Hundred Fifty-four, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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