Extended vs. Intermittent Beta-Lactam Infusion in ICU Sepsis

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Conditions studied: Sepsis, Septic Shock

In brief

This observational study compares extended versus intermittent beta-lactam infusion in sepsis patients, assessing survival, clinical cure rates, and practical ICU challenges. The findings will guide optimal antibiotic protocols, potentially improving sepsis outcomes through precision dosing strategies.

Key facts

Study ID

NCT07398703

Run by

Assiut University

People needed

50

Starts

2026-10-01

Expected to finish

2027-10-01

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged: 18 - 65
• Patients admitted to critical care unit diagnosed with pneumonia or urinary tract infection with two of the following:
• Temperature: over 38 degree celsius
• Heart rate: over 100 beats per minute
• Respiratory rate: over 20 breaths per minute
• leucocyte count over than 12000 or less than 4000 microlitres or over 10% immature forms or bands
• Patients with positive sputum or urine cultures

You may not qualify if…

• Hypersensitivity to Beta-lactams
• Pregnancy
• Very low probability of survival using APAACHE II score > 34 points.
• Immunodeficency or taking immunosuppressive medications
• Acute or chronic renal failure with creatinine clearance less than 30 ml/min according to Cockcroft-Gault formula.

Full record on ClinicalTrials.gov

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