Gastric Content in Fasting Volunteers and in Tirzepatide Users: an Observational and Cross-sectional Study
Recruiting now
Conditions studied: Full Stomach Status
In brief
Introduction Obesity and type 2 diabetes mellitus constitute a global public health problem. Medications with glucagon-like peptide-1 (GLP-1) receptor agonist activity are a modern therapeutic option for both diseases. Liraglutide, semaglutide, dulaglutide and tirzepatide are representatives of this drug class, whose mechanism of action results in delayed gastric emptying, reduced gastric motility and increased gastric volume. Tirzepatide, however, presents a dual agonist action, combining GLP-1 agonism with glucose-dependent insulinotropic polypeptide (GIP) agonism. The presence of gastric content during anaesthesia may lead to pulmonary aspiration and the development of chemical pneumonitis, a potentially devastating complication. However, when there is a risk factor for delayed gastric emptying, despite adequate fasting, the stomach may still present residual content, and bedside ultrasonography is an effective, non-invasive and rapid method to measure this content and stratify aspiration risk. Our hypothesis is that most individuals using tirzepatide present a full stomach even after fasting times recommended in the literature.
Key facts
- Study ID
- NCT07398222
- Run by
- Hospital Israelita Albert Einstein
- People needed
- 30
- Starts
- 2026-01-26
- Expected to finish
- 2026-03-20
- Last updated by the study team
- 2026-02-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18 years or older.
- Individuals currently using tirzepatide.
- Individuals fasting for at least 8 hours for solids and 2 hours for clear liquids without residue.
You may not qualify if…
- Pregnant or postpartum individuals.
- Technical limitation for gastric ultrasound assessment.
- Presence of risk factors for gastroparesis.
- Use of prokinetic medications such as bromopride, metoclopramide or domperidone.
Where it is running
- Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.