Sodium-rich COndiments Unifying Health and Taste

Recruiting now · Not applicable

Conditions studied: Elevated Blood Pressure, Vascular Health, Sensory Evaluation

In brief

This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such an index that will systematically classify sodium-rich condiments based on the risk they present to cardiovascular health.

Key facts

Study ID

NCT07397754

Run by

Singapore Institute of Food and Biotechnology Innovation

People needed

32

Starts

2025-09-22

Expected to finish

2026-09-22

Last updated by the study team

2026-02-09

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ≥ 50, < 75 years old
• Male or postmenopausal female (self-reported)
• ≥ 50 kg body weight
• Systolic blood pressure (≥ 130, < 160 mmHg) or diastolic blood pressure (≥ 85, < 100 mmHg)
• Willing and able to follow intervention protocol
• Ability to identify basic tastes (determined by taste discrimination test)
• English speaking

You may not qualify if…

• Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh)
• Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol/L or HbA1c ≥ 6.5 %)
• Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team
• Obesity (BMI ≥ 27.5 kg/m2)
• History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease / disorders which may affect the outcomes of interest in consultation with study physician, PI and study team
• History of arteriovenous shunt or mastectomy
• Women who are pregnant, lactating or planning pregnancy
• History or present diagnosis of HIV and/or tuberculosis
• History of severe vasovagal syncope (blackouts or near faints) following blood draw
• Drug abuse within last 5 years
• Excessive alcoholic beverage consumption > 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
• Smoking (cigarette, e-cigarette, cigar, pipe, vape)
• Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR)
• Allergic or intolerance to intervention foods.
• Dislike or unwilling to consume intervention foods
• Photophobic (sensitivity to intense lights and colours), particularly to intense red lights
• Has sinus problems problems that affect taste and smell
• Involvement in other clinical studies that may influence the outcome of the study
• An ASTAR Staff.
• A study team member or their immediate family member

Where it is running

• Clinical Nutrition Research Centre — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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