" TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus

Recruiting now

Conditions studied: Systemic Lupus Erythematosus

In brief

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by diverse clinical manifestations, prominently involving the skin.

Key facts

Study ID

NCT07397728

Run by

South Valley University

People needed

90

Starts

2025-06-10

Expected to finish

2026-06-10

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult aged 18-60 years
• Diagnosed as SLE per 2019 EULAR/ACR classification criteria.
• Presence of at least one cutaneous manifestation (acute, subacute, or chronic).
• Willing to provide written informed consent for participation and genetic testing

You may not qualify if…

• Overlap autoimmune syndromes (e.g., dermatomyositis, systemic sclerosis).
• Systemic infection, malignancy, or pregnancy.
• Use of biologic therapy or immunosuppressive pulses within one month.

Where it is running

• Qina University hospital, South Valley University Hospital — Qina, South Valley, Egypt (enrolling)

Full record on ClinicalTrials.gov

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