stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database
Recruiting now
Conditions studied: Breast Cancer, Oligometastasis
In brief
Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases. In addition to standard treatments that act on the whole body, such as chemotherapy or hormonal therapy, these patients might also benefit from local treatments that directly target the cancer spots. One of these local treatments is stereotactic body radiotherapy (SBRT), a non-invasive radiation treatment that delivers high doses of radiation in a few sessions. In the past, most of the evidence about the benefit of local treatments came from surgery. More recently, there has been growing interest in SBRT because it does not require surgery. However, the results of studies so far have not been consistent.The goal of this multicenter retrospective study is to better understand whether SBRT can improve disease control and survival in patients with breast cancer that has spread to a limited number of sites outside the brain.
Key facts
- Study ID
- NCT07397585
- Run by
- Istituto Clinico Humanitas
- People needed
- 300
- Starts
- 2025-02-25
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-02-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ≥18 years
- Histological diagnosis of breast cancer
- Oligometastatic or oligoprogressive metastatic breast cancer
- SBRT delivered to a minimum dose of 50Gy EQD2 (αβ 10 Gy),in a maximum of 12 fractions as per Oligocare definition
- Ability to provide written informed consent
Where it is running
- Irccs Crob — Rionero in Vulture, PZ, Italy (enrolling)
- INT IRCCS Fondazione G. Pascale — Naples, Napoli, Italy (enrolling)
- Ospedale Maggiore della Carita — Novara, NOVARA, Italy (enrolling)
- Fondazione Policlinico Universitario, Campus-Biomedico — Roma, Roma, Italy (enrolling)
- Responsible Research Hospital — Campobasso, CB, Italy (enrolling)
- Fondazione I.R.C.C.S Istituto Nazionale Tumori di Milano — Milan, MILANO, Italy (enrolling)
- Humanitas Gavazzeni — Bergamo, Bergamo, Italy (enrolling)
- IRCCS Humanitas Research Humanitas — Rozzano, MILANO, Italy (enrolling)
- Spedali Civili — Brescia, BS, Italy (enrolling)
- Azienda Ospedaliera Universitaria Pisana — Pisa, PI, Italy
- IRCCS Centro di Riferimento Oncologico di Aviano — Aviano, Pordenone, Italy
- Uo Radioterapia Aor San Carlo — Potenza, PZ, Italy
- UOC Radioterapia Ospedale San Filippo Neri — Roma, RM, Italy
- Azienda Ospedaliera San Giovanni Addolorata — Roma, RM, Italy
- Fondazione PTV Policlinico Tor Vergata — Roma, Roma, Italy
- Azienda Ospedaliera Sant'Andrea — Roma, Roma, Italy
- S.C. Radioterapia Oncologica ASL Taranto — Taranto, Taranto, Italy
- Radioterapia Oncologica - Ospedale Sanata Chiara — Trento, TRENTO, Italy
- Aorn San Pio — Benevento, Benevento, Italy
- S.C. Radioterapia Oncologica - Azienda Ospedaliera Santa Maria Terni — Terni, TR, Italy
- Ospedale Perrino — Brindisi, BR, Italy
- Azienda Ospedaliera Universitaria Careggi — Florence, Firenze, Italy
- Irccs Ospedale Policlinico San Martino — Genova, Genova, Italy
- A.O.U. "G. Martino" - Università degli Studi di Messina — Messina, Messina, Italy
- IEO — Milan, Milano, Italy
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.