Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis

Recruiting now · Not applicable

Conditions studied: Knee Osteoarthristis, Osteearthritis, Knee Pain Arthritis

In brief

A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.

Key facts

Study ID

NCT07396233

Run by

University of Karachi

People needed

150

Starts

2026-02-07

Expected to finish

2027-02-22

Last updated by the study team

2026-02-11

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Both male and females with an age range between 40-60 years.
• Patients diagnosed with unilateral or bilateral Knee OA.
• Grade-II or grade-III on kellgren and Lawrence classification.
• Patients having pain intensity more than 3.4 cm on VAS as minimum cut off value.
• Duration of knee OA more than 3 months (chronic).

You may not qualify if…

• Patients with any neurological disorder.
• History of lower limb arthroplasty or any other knee surgery.
• Septic knee arthritis.
• Inflammatory rheumatic disease such as rheumatoid arthritis and gout.
• Cancer or any other malignancy such as bone tumor.
• Knee deformities such as contracture, genu valgum and genu varum.
• History of ligamentous injury and meniscal tear.

Where it is running

• Al-Rayaz Hospital — Karachi, Sindh, Pakistan (enrolling)
• Dr. Ziauddin Hospital — Karachi, Sindh, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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