A Study on Rosa Roxburghii for Knee Replacement Recovery

Starting soon · Not applicable · Has a placebo group

Conditions studied: Osteoarthritis

In brief

This clinical trail is to investigates the effect of Rosa roxburghii juice freeze-dried powder on the recovery of patients undergoing total knee arthroplasty due to knee osteoarthritis. The participants are divided into an experimental group and a placebo group. Enrolled patients will take 3g of Rosa roxburghii juice freeze-dried powder or a placebo dissolved in 400-500ml of warm water with breakfast daily, starting from the day after surgery and continuing for 30 consecutive days. Data on inflammatory markers, oxidative stress indicators, and knee function scores will be collected from the participants one day before surgery, as well as on the first, third, and thirtieth days after surgery.

Key facts

Study ID

NCT07395856

Run by

Shuguang Gao

People needed

184

Starts

2026-01-15

Expected to finish

2027-02-15

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnostic criteria for primary knee osteoarthritis (KOA) as defined by the "Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2019 Edition)."
• Aged between 18 and 75 years.
• No history of trauma or surgery involving the lower limbs. Scheduled to undergo total knee arthroplasty (TKA) performed by the same surgical team at the participating hospital.
• Willing to refrain from participating in any other clinical research studies for the duration of this trial.
• Agrees to adhere to the complete study treatment regimen.
• Able and willing to provide written informed consent.

You may not qualify if…

• Has a preoperative knee joint infection, rheumatoid arthritis, or other concurrent inflammatory or non-inflammatory joint disease.
• Has a history of any prior knee surgery (including revision procedures).
• Has diabetes mellitus with poorly controlled glucose levels (fasting blood glucose >7.2 mmol/L or 2-hour postprandial blood glucose >11.1 mmol/L).
• Has severe, unstable, or uncontrolled disease of the circulatory, respiratory, or hematopoietic systems.
• Has obesity defined as a body mass index (BMI) ≥30 kg/m².
• Has a diagnosis of severe osteoporosis.
• Is pregnant or currently breastfeeding.
• Has an active psychiatric disorder or any other condition that, in the investigator's judgment, would impair the ability to provide informed consent or comply with study procedures.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.