Postoperative Results and Outcomes in Surgical Pelvic Exenteration
Enrolling by invitation
Conditions studied: Rectal Cancer Recurrent, Pelvic Exenteration, Advanced Rectal Cancer
In brief
The purpose of this study is to evaluate the feasibility of a standardized surgical and care process for patients with locally advanced or recurrent rectal cancer that has spread to nearby pelvic organs. When cancer invades adjacent structures (such as the sacrum, bladder, or prostate), a complex procedure called pelvic exenteration (PE) is often required to remove the tumor entirely. This research does not involve testing new or experimental surgical techniques. All procedures performed in this study are part of standard clinical practice. Instead, the focus of this project is to: Standardize Procedures: Create consistent, high-quality steps for the surgical team to follow. Improve Teamwork: Enhance coordination between different medical specialists (such as colorectal surgeons, urologists, and oncologists) to provide better care. Track Outcomes: Use a patient registry to monitor clinical data and quality of life after surgery through patient-reported surveys. A total of 24 adult patients will be enrolled over a three-year period. By refining these workflows and monitoring patient recovery, the study aims to ensure that these complex surgeries are performed as safely and effectively as possible.
Key facts
- Study ID
- NCT07395505
- Run by
- Chang Gung Memorial Hospital
- People needed
- 24
- Starts
- 2025-11-01
- Expected to finish
- 2029-02-01
- Last updated by the study team
- 2026-02-09
Who can join
Age: 20 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients aged ≥20 years.
- Histologically confirmed rectal adenocarcinoma or anal adenocarcinoma.
- Tumor invasion of sacrum (requiring sacrectomy, S2-S4) or anterior structures (e.g., prostate), or lateral structures(SLAM, vessels, nerve) where resection of the invaded organ is necessary to achieve R0 resection, as determined by MDT.
- Surgical candidacy confirmed by multidisciplinary review (colorectal surgery, urology, orthopedics, oncology, radiology, pathology).
- Preoperative imaging (MRI, PET/CT) confirming resectable disease without distant metastasis.
- Signed informed consent obtained.
You may not qualify if…
- Unresectable disease or widespread distant metastasis.
- Severe comorbidities rendering major surgery or anesthesia unsafe.
- Patients unable to complete postoperative follow-up or unwilling to participate in PROMs assessment.
Where it is running
- Chang Gung Memorial Hospital, Linkou — Taoyuan, Taiwan
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.