Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Recruiting now · Not applicable
Conditions studied: Polycystic Ovary Syndrome (PCOS), Female Infertility
In brief
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Key facts
- Study ID
- NCT07394530
- Run by
- Hanoi General Hospital (Vietnam)
- People needed
- 400
- Starts
- 2026-01-20
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged 18-40 years
- Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
- Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
- Eligible for controlled ovarian stimulation for IVF
- Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
- Willing and able to provide written informed consent and comply with study procedures.
You may not qualify if…
- Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
- History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
- History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
- Known chromosomal abnormalities in either partner
- Inability to adhere to study protocol or follow-up procedures
Where it is running
- Hanoi General Hospital — Hanoi, Hanoi, Vietnam (enrolling)
Full record on ClinicalTrials.gov
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