Effect of Add-on L-Arginine Therapy on Heart Failure Patients

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Heart Failure

In brief

Heart failure is considered one of the greatest challenges globally. There are various treatment strategies for heart failure. L-Arginine is an amino acid that was found to have beneficial effect on vasculature. This study aims to study the benefits and side effects of using L-arginine on the patients with ejection fraction \<40%

Key facts

Study ID

NCT07394270

Run by

German University in Cairo

People needed

200

Starts

2026-02-01

Expected to finish

2027-07-01

Last updated by the study team

2026-02-06

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with EF <40%
• eGFR >30 mL/min/1.73 m2
• Stable patients
• Capable and willing to provide written consent

You may not qualify if…

• Patients with implantable cardioverter-defibrillator
• Pregnant or lactating fmeales
• Patients with a history of sensitivity to L-Arginine or any of the excipients
• Acute heart failure patients
• Patients use L-arginine supplementation.
• Patients with active herpes disease

Where it is running

• Ain Shams University — Cairo, Egypt

Full record on ClinicalTrials.gov

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