Effect of Ipratropium Bromide on EILO
Starting soon · Phase 2 · Has a placebo group
Conditions studied: Exercise-Induced Laryngeal Obstruction, Dyspnea During Activity
In brief
The investigators propose a study that compares breathlessness and airway obstruction during intense exercise in 34 children and adolescents with Exercise-Induced Laryngeal Obstruction after breathing in ipratropium bromide or placebo. It is hypothesized that breathlessness and airway obstruction will be lower following breathing in ipratropium bromide compared with placebo.
Key facts
- Study ID
- NCT07394036
- Run by
- Cook Children's Health Care System
- People needed
- 50
- Starts
- 2026-06-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-05-05
Who can join
Age: 8 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must be diagnosed with EILO confirmed by Continuous Laryngoscopy During Exercise
- Patients must be able to complete exercise testing
- Patients must report dyspnea
- Patients must have given assent with parental consent, understand all study procedures, and comply with them for the entire length of the study.
You may not qualify if…
- Patients that do not have EILO.
- Patients who did not undergo diagnostic CPET with CLE.
- Patients with hypersensitivity to atropine or its derivatives due to structural similarity with ipratropium bromide.
- Patients with a history of atrial flutter and/or fibrillation
- Patients taking anticholinergic medications that cannot be paused for 24 hours.
- Unable to perform exercise tests
- Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
- Inability or unwillingness of patient or parent/legally authorized representative to give written informed consent.
Where it is running
- Cook Children's Pulmonology (Exercise Respiratory Center) — Prosper, Texas, United States
Full record on ClinicalTrials.gov
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