Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin
Recruiting now · Not applicable
Conditions studied: Tooth Loss, Tooth Diseases, Reimplant; Complications
In brief
Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.
Key facts
- Study ID
- NCT07393997
- Run by
- University of Bari Aldo Moro
- People needed
- 5
- Starts
- 2026-01-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-02-06
Who can join
Age: 10 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Autotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:
- Early loss of permanent teeth due to trauma, extensive caries, or agenesis.
- Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.
- Replacement of non-restorable teeth (fractures or destructive caries).
- Preservation of alveolar bone in growing patients where implant therapy is contraindicated.
- Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients.
- Post-traumatic oral rehabilitation in young patients.
- Good general and oral health.
- Presence of a vital and intact periodontal ligament on the donor tooth.
- Adequate recipient site dimensions and morphology, or surgically adaptable.
- Absence of active infection at the recipient site. Donor Tooth Selection Criteria
- Tooth extracted for orthodontic purposes.
- Impacted or erupting third molars with compatible morphology.
- Suitable supernumerary teeth.
You may not qualify if…
- Poor patient compliance.
- Active infection at the recipient site.
- Smoking of more than 15 cigarettes a day
- . Untreated periodontal disease
- Pregnancy or breastfeeding at date of inclusion
- Acute infections
Where it is running
- University of Bari Aldo Moro, Hospital — Bari, Italy (enrolling)
Full record on ClinicalTrials.gov
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