Molecular Indicators of Systematic Fitness
Recruiting now
Conditions studied: Healthy Adult, Fitness Testing, Athlete, Aging, Exercise Physiology, Human Performance
In brief
The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are: 1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak? 2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles? 3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)? 4. What is the analytic reliability of the predictor biomarkers?
Key facts
- Study ID
- NCT07393841
- Run by
- VO Health, Inc.
- People needed
- 250
- Starts
- 2026-01-05
- Expected to finish
- 2028-05-10
- Last updated by the study team
- 2026-02-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Be ≥18 years old
- Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
- Be willing to complete VO₂max testing, blood draw, and questionnaires.
- Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)
You may not qualify if…
- Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
- Contraindications or unwillingness to undergo venipuncture
- Acute illness (fever, significant respiratory illness) at the time of testing
- Failure to comply with procedures.
Where it is running
- VO Health, Inc. — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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