Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth
Starting soon · Phase 3 · Has a placebo group
Conditions studied: Mouthwash, Chlorhexidine, Biofilm Formation, Periodontal Health
In brief
Dental plaque is a biofilm that accumulates on tooth surfaces and is a primary factor in the development of gingival inflammation. While toothbrushing remains the main method for plaque control, the effectiveness of mechanical oral hygiene depends largely on individual compliance and technique. As a result, mouthwashes are commonly used as adjunctive chemical plaque control agents. Chlorhexidine gluconate is an effective anti-plaque mouthwash, but its use is associated with undesirable effects that may limit patient acceptance. Resveratrol is a naturally derived compound with reported antimicrobial and anti-biofilm properties, suggesting its potential use as an alternative chemical plaque control agent. This randomized, double-blind, placebo-controlled, three-period crossover clinical trial aims to evaluate the short-term anti-plaque effect of a resveratrol-based mouthwash by measuring supragingival plaque regrowth over a 24-hour period in periodontally healthy individuals. The effects of the resveratrol-based mouthwash will be compared with 0.12% chlorhexidine (CHX) and a placebo mouthwash under standardized conditions without mechanical oral hygiene
Key facts
- Study ID
- NCT07393802
- Run by
- University of Baghdad
- People needed
- 20
- Starts
- 2026-03-01
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2026-02-06
Who can join
Age: 18 and older, up to 25. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age between 18 and 30 years
- Systemically healthy individuals
- Presence of at least 20 natural teeth
- Clinically healthy gingiva with no signs of gingivitis or periodontitis
- No probing depth >3 mm
- No clinical attachment loss
You may not qualify if…
- Presence of gingivitis or periodontitis
- Active dental caries requiring treatment
- History of periodontal therapy within the previous 6 months
- Use of antibiotics, anti-inflammatory drugs, or antiseptic mouthwashes within the previous 3 months
- Smoking or tobacco use
- Pregnancy or lactation
- Known allergy to any mouthwash components
Where it is running
- Ahmed Hashim — Karbala, Iraq
Full record on ClinicalTrials.gov
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