Metaphylaxis of Infected Kidney Stones After Percutaneous Nephrolithotripsy

Starting soon · Not applicable

Conditions studied: Kidney Calculi, Nephrolithiasis, Urinary Tract Infections

In brief

Kidney stone recurrence, particularly infection-related stones, remains a significant clinical problem after percutaneous nephrolithotripsy (PCNL). Bacterial colonization and persistent infection are recognized contributors to stone recurrence. This study evaluates the effectiveness of intrarenal dioxidine instillation as a metaphylactic measure to reduce recurrence of infection-related kidney stones following PCNL. Patients undergoing PCNL will receive standard treatment, with or without adjunctive intrarenal dioxidine administration. The study aims to assess whether this approach reduces stone recurrence and infection-related complications.

Key facts

Study ID

NCT07393711

Run by

West Kazakhstan Marat Ospanov Medical University

People needed

95

Starts

2026-03-01

Expected to finish

2026-12-30

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Patients undergoing percutaneous nephrolithotripsy (PCNL)
• Infection-related kidney stones
• Ability to provide written informed consent

You may not qualify if…

• Age <18 years
• Pregnancy or breastfeeding
• Known hypersensitivity to dioxidine
• Severe renal insufficiency or end-stage renal disease
• Severe comorbid conditions that preclude participation

Where it is running

• West Kazakhstan Marat Ospanov Medical University — Aqtöbe, Kazakhstan

Full record on ClinicalTrials.gov

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