A Clinical Study of SH006 Injection in Combination Therapy Versus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma
Starting soon · Phase 2/Phase 3
Conditions studied: Hepatocellular Carcinoma (HCC)
In brief
To evaluate the efficacy and safety of the combination therapy of SH006 injection in the treatment of advanced hepatocellular carcinoma
Key facts
- Study ID
- NCT07392866
- Run by
- Nanjing Sanhome Pharmaceutical, Co., Ltd.
- People needed
- 120
- Starts
- 2026-03-01
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2026-02-09
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects participate voluntarily and sign informed consent.
- Age ≥ 18 and ≤ 75 years old, male or female.
- Histological or clinical diagnosis of HCC.
- Barcelona Clinic Liver Cancer stage C. BCLC stage B, not suitable for radical surgery and/or local treatment
- Previous treatment with a drug containing an immune checkpoint inhibitor failed.
- Child-Pugh ≤7 , no history of hepatic encephalopathy.
You may not qualify if…
- Histologically documented fibrolamellar hepatocellular carcinoma, sarcoma-like hepatocellular carcinoma, etc.
- History of malignancy other than HCC within 5 years prior to the start of study treatment.
- History of liver transplantation, or planned to receive liver transplantation.
- Moderate or severe ascites with clinical symptoms that require drainage, uncontrolled or moderate or severe pleural and pericardical effusion.
- Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Involvement of both the main portal vein and the left and right branches by portal vein tumor thrombus, or of both the main trunk and the superior mesenteric vein concurrently, or of inferior vena cava.
Where it is running
- Nanjing Tianyinshan Hospital — Nanjing, Jiangsu, China
- Zhongshan Hospital, Fudan University — Shanghai, Shanghai Municipality, China
Full record on ClinicalTrials.gov
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