Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone

Starting soon

Conditions studied: Postoperative Cognitive Dysfunction

In brief

The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal anesthesia.

Key facts

Study ID

NCT07392840

Run by

Minia University

People needed

50

Starts

2026-02-01

Expected to finish

2027-04-01

Last updated by the study team

2026-02-10

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients of both genders ageing 65 years or above.
• ASA grade I to III.
• Undergo elective lower limb surgery under spinal anesthesia
• Agree to collect one's own CSF and blood samples

You may not qualify if…

• Past history of depression,anxiety,delirium and schizophrenia .
• Past history of drug dependence.
• Past history of dementia,including Alzheimer disease(AD).
• Preoperative Montreal Cognitive Assessment (MoCA) score <26.
• Inability to understand or cooperate with the evaluation scale or questionnaire.
• Refuse collecting one's own CSF and blood samples.

Full record on ClinicalTrials.gov

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