Nitroglycerin Ointment for Pain Relief After Endoscopic Hemorrhoid Band Ligation

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Internal Hemorrhoids, Postoperative Pain After Endoscopic Rubber Band Ligation

In brief

This study is designed to evaluate whether nitroglycerin ointment can reduce pain after endoscopic rubber band ligation for internal hemorrhoids. Endoscopic rubber band ligation is a commonly used, minimally invasive treatment for internal hemorrhoids, but postoperative anal pain is a frequent and sometimes severe complication that can affect daily activities and recovery. Participants undergoing endoscopic rubber band ligation will be randomly assigned to receive either nitroglycerin ointment or a placebo ointment applied locally after the procedure. Both participants and investigators will be blinded to the treatment assignment. All participants will receive the same standard perioperative care, and rescue pain medication will be provided when necessary. The primary goal of the study is to compare the proportion of patients who require rescue pain medication within 72 hours after the procedure between the two groups. Secondary outcomes include pain intensity at multiple time points, time to complete pain relief, postoperative complications, treatment-related adverse events, and overall treatment effectiveness at 30 days. The results of this study may help identify a safe and effective option for improving pain control after endoscopic treatment of internal hemorrhoids.

Key facts

Study ID

NCT07391501

Run by

Ying Zhu

People needed

68

Starts

2026-02-01

Expected to finish

2028-11-30

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 18 to 75 years, male or female
• Diagnosis/indication: Internal hemorrhoids grade I, II, or III scheduled for endoscopic rubber band ligation
• Consent: Able and willing to participate and provide written informed consent

You may not qualify if…

• Compliance/assessment: Unable to understand study endpoints or complete study records/forms
• Concomitant medications: Current use of oral nitrates or calcium channel blockers
• Allergy: Known allergy to lactulose oral solution, nitroglycerin ointment, or other study-related medications
• Pregnancy/lactation: Pregnant or breastfeeding women
• Procedure tolerance: Unable to tolerate hemorrhoid band ligation, colonoscopy, or bowel preparation
• Severe comorbidities: Severe cardiac, respiratory, neurologic, or psychiatric disorders
• Legal capacity: Lacking legal capacity for civil conduct or lacking insight/judgment to provide valid consent

Full record on ClinicalTrials.gov

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