Peripheral Perfusion and Outcomes in ICU Patients With Sepsis

Starting soon

Conditions studied: SEPSIS, Septic Patients

In brief

People with sepsis who are treated in the intensive care unit (ICU) often have impaired blood flow to the skin and other tissues. These alterations in tissue perfusion may be associated with disease severity and clinical outcomes. The aim of this study is to see whether simple signs of blood flow to the skin, such as capillary refill time and blood test measurements, are linked to outcomes in people with sepsis treated in the ICU. Adults with sepsis who are admitted to the ICU will be invited to take part. Researchers will collect routine clinical data and blood test results during the first day of ICU treatment. No extra procedures or treatments will be performed as part of the study. The results of this study may improve understanding of early signs of impaired circulation in sepsis and their relation with recovery and survival.

Key facts

Study ID

NCT07391098

Run by

Alexandra Elena Lazăr

People needed

80

Starts

2026-02-02

Expected to finish

2026-09-30

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults aged 18 years or older
• admission to the intensive care unit
• sepsis or septic shock, defined according to Sepsis-3 criteria
• SOFA score ≥ 2 at inclusion
• presence of an arterial line and a central venous catheter suitable for blood sampling
• possibility to perform peripheral perfusion assessment (CRT) at predefined time points

You may not qualify if…

• age under 18 years
• pregnancy
• expected ICU stay less than 24 hours
• limitations of therapy at ICU admission (e.g., DNR or comfort-only care)
• improper central venous catheter position (catheter tip not located in the superior vena cava)
• absence of arterial or central venous access required for paired blood gas sampling
• refusal of consent, when applicable according to local ethics requirements

Where it is running

• Emergebcy Clinical County Hospital - Intensive Care Clinic — Târgu Mureş, Mureș County, Romania

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.