A Study of Neuropathy Caused by Enfortumab Vedotin in People With Urothelial Carcinoma

Recruiting now

Conditions studied: Neuropathy, Urothelial Carcinoma, Metastatic Urothelial Carcinoma

In brief

The purpose of this study is to see how results of nerve tests change in people with urothelial cancer who receive treatment with enfortumab vedotin (EV)

Key facts

Study ID

NCT07390617

Run by

Memorial Sloan Kettering Cancer Center

People needed

50

Starts

2026-01-20

Expected to finish

2028-01-20

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent by and HIPAA authorization for release of personal health information obtained from the research participant.
• Able to speak and read English to a sufficient level of fluency to provide informed consent and complete the study questionnaires.
• Age ≥ 18 years at the time of consent.
• ECOG Performance Status of ≤ 3 within 28 days prior to consent.
• Histological or cytologically confirmed urothelial carcinoma.
• Patients must be planned to start systemic therapy with enfortumab vedotin
• At time of enrollment, patients must be planned to start enfortumab with or without pembrolizumab

You may not qualify if…

• Subjects meeting any of the criteria below may not participate in the study:
• Inability of the subject to understand and comply with study procedures.
• Having previously received enfortumab vedotin
• Students/employees of the study institution, pregnant women, prisoners, and institutionalized individuals (to prevent enrollment of vulnerable subjects).

Where it is running

• Memorial Sloan Kettering Cancer Center Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities) — Commack, New York, United States (enrolling)
• Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center (All Protocol Activites) — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Nassau (Limited Protocol Activites) — Rockville Centre, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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