Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy

Recruiting now · Not applicable

Conditions studied: Lymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity Syndrome

In brief

The proposed multimodal telerehabilitation model allows a rehabilitation therapy team to set up individualized rehabilitation plans using a web-based care management portal and monitor patient progress online. Patients at home follow a safe and effective personalized exercise and nutrition plan guided by interactive touch-screen technology combined with behavioral counseling, social support, and interactive education and empowerment. The design of the telerehabilitation system is based on the cloud-based Internet-of-Things architecture allowing real-time monitoring of cardiovascular parameters and exercise performance. The patient's level of exertion during exercise is automatically identified by a validated AI-driven algorithm supporting exercise safety and efficacy. The ultimate goal of this pilot feasibility project is to establish the extent of the impact of the proposed patient-centered cancer telerehabilitation model on disease-specific quality of life, and functional and symptom outcomes and to obtain sufficient evidence for a definitive randomized clinical trial evaluating this approach in a multi-center study.

Key facts

Study ID

NCT07390071

Run by

University of Utah

People needed

40

Starts

2025-09-01

Expected to finish

2029-01-01

Last updated by the study team

2026-02-05

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age >21
• confirmed diagnosis of lymphoma or myeloma
• commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
• Access to a working telephone line in their home or a cell phone.

You may not qualify if…

• have unstable angina, uncontrolled hypertension, recent myocardial infarction, pacemakers, painful or unstable bony metastases, or recent skeletal fractures;
• are engaged in a regular exercise rehabilitation program;
• have relocation plans within next 6 months;
• participate in another clinical trial.

Where it is running

• Huntsman Cancer Institute at University of Utah — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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