Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation
Starting soon · Phase 4
Conditions studied: Atrial Fibrillation (AF)
In brief
To evaluate whether pre-treatment with semaglutide is superior to standard care in improving freedom from atrial fibrillation (AF) at 12 months following catheter ablation in patients with obesity and symptomatic AF undergoing first-time ablation.
Key facts
- Study ID
- NCT07389941
- Run by
- University of Luebeck
- People needed
- 240
- Starts
- 2026-10-01
- Expected to finish
- 2029-04-01
- Last updated by the study team
- 2026-02-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-80 years
- Symptomatic paroxysmal or persistent AF eligible for first-time catheter ablation
- Body mass index ≥30 kg/m or body mass index ≥28 kg/m plus ≥1 weight-related comorbidity
- No prior treatment with glucacon-like peptide-1 receptor agonists
You may not qualify if…
- Current use of glucacon-like peptide-1 receptor agonists or dipeptidyl peptidase 4 inhibitors or use within the last 90 days prior to screening
- Current antiobesity medication use or use within the last 90 days prior to screening
- A self-reported change in body weight of >5 kg within 30 days before screening
- History of bariatric surgery
- History of diabetes mellitus
- Hospitalization for unstable angina, or transient ischemic attack <30 days prior to screening
- Pulmonary embolism <90 days before screening
- Myocardial infarction, or stroke <90 days prior to screening
- Uncontrolled thyroid disease: thyroid-stimulating hormone >10.0 mIU/L or <0.4 mIU/L at screening
- Active malignancy
- Acute pancreatitis <180 days before screening
- History or presence of chronic pancreatitis
- Chronic kidney disease with creatinine clearance <30 mL/min
- Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
- Chronic inflammatory conditions requiring immunosuppression and/or on glucocorticoids
- Pregnancy, breast-feeding or planning pregnancy
Full record on ClinicalTrials.gov
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