INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT

Enrolling by invitation

Conditions studied: Type 2 Diabetes

In brief

The subject of this thesis study is the effects of SWEEPS laser and ultrasonic activation methods on the immune response in the treatment of apical periodontitis in healthy individuals and patients with Type 2 diabetes requiring retreatment, based on a comparative investigation of Toll-like Receptor 9 (TLR-9), Interleukin-6 (IL-6) and Tumour Necrosis Factor alpha (TNF-α), and Interleukin-10 (IL-10) levels.

Key facts

Study ID

NCT07389772

Run by

bengisu yüksel

People needed

90

Starts

2026-01-28

Expected to finish

2027-05-15

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion criteria for the study:
• Patients aged 18-50 years
• Patients with ASA I status
• Patients with Type 2 diabetes whose HbA1c values are between 5.5% and 9.0%, with diabetes diagnosis confirmed by medical history and laboratory tests (HbA1c test)
• Upper and lower incisors and lower premolars with chronic apical periodontitis,
• Teeth requiring retreatment with a PAI score ≥3 will be included in the study. (15)

You may not qualify if…

• ASA II or higher,
• Pregnant women or those suspected of being pregnant,
• Patients with localized or generalized periodontitis,
• Patients with inflammatory or autoimmune diseases such as hepatitis, HIV infection, immunosuppressive chemotherapy, bleeding disorders, Behçet's syndrome, and arthritis,
• Individuals with HbA1c levels above 9%,
• Those who have used antibiotics within the last month and anti-inflammatory drugs within the last week, 6. Smokers, 7. Patients with periodontal pockets greater than 3 mm in the relevant tooth, 8. Those with internal or external root resorption, 9. Those with swelling, palpation pain, or a fistula in the relevant area, 10. Those with root fracture or incomplete root formation, 11. Teeth that cannot be isolated with a rubber dam will not be included in the study.
• The name, surname, age, gender, contact information, and tooth number to be treated of patients included in the study will be recorded on the case report form. Periapical radiographs will be taken of the relevant teeth prior to root canal treatment to examine the root canal anatomy. The periapical health status of each tooth will be assessed using the PAI score.

Where it is running

• Kirikkale University Faculty of Dentistry — Kirikkale, Kırıkkale, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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