Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Recruiting now · Phase 4
Conditions studied: Opioid Free Anesthesia
In brief
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.
Key facts
- Study ID
- NCT07389096
- Run by
- Nashwa Ahmed
- People needed
- 30
- Starts
- 2026-01-30
- Expected to finish
- 2027-01-31
- Last updated by the study team
- 2026-02-05
Who can join
Age: 8 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Port said university — Port Said, Egypt (enrolling)
Full record on ClinicalTrials.gov
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