Study to Evaluate the Feasibility of Syde® Digital Endpoints for Monitoring Patients With Progressive Supranuclear Palsy - Richardson Syndrome (PSP-R)

Starting soon

Conditions studied: Progressive Supranuclear Palsy- Richardson Syndrome (PSP-R)

In brief

The study aims to assess the feasibility/acceptability of real-world activity monitoring by the Syde® wearable device in PSP-R. The Syde® collected data will be compared to on-site conventional clinical endpoints, including functional capacity and cognitive assessments, as well as core scales assessments.

Key facts

Study ID

NCT07389018

Run by

SYSNAV

People needed

30

Starts

2026-05-01

Expected to finish

2028-03-01

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years old or older
• Participants affiliated to, or beneficiary from, a social security.
• Ambulant patients (i.e. able to walk 10 meters without assistance)
• Signed informed consent form by the patient himself or, by caregivers if the patient is not capable to fill, date and sign the form due to fine motor function difficulties..
• Possible or probable PSP-R according to MDS criteria 2017(Hoglinger et al., Mov Disorder, 2017).

You may not qualify if…

• Patients with extreme cognitive disorders that limit their understanding of the data collection process (training of device use and 4-week recording periods every 4 months, device return at the end of the study), tests to be performed including eye movement recording (every 8 months), the implication of the study and consent.
• Patients who do not tolerate to keep the sensors on their ankles.
• Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the lower limbs.
• A concomitant chronic or acute neurological, endocrine, infectious, allergic, or inflammatory pathology within the 3-week period immediately prior to inclusion.
• Patients affected by any other disorder having a significant impact on gait or lower limb function.
• Participant covered by a legal protection measure (guardianship, curatorship or safeguarding of justice) or who is unable to express their consent.
• Absence of caregiver.

Where it is running

• Hôpital Fondation Adolphe de Rothschild — Paris, France

Full record on ClinicalTrials.gov

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