Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy

Recruiting now

Conditions studied: Reproductive Issues

In brief

Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT). Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer Secondary outcomes: Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.

Key facts

Study ID

NCT07388797

Run by

Chinese University of Hong Kong

People needed

370

Starts

2026-01-20

Expected to finish

2028-12-31

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older, up to 42. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing FET cycles
• Infertility patients aged >18 years old and < 42 years old
• BMI < 30 kg/m2
• Transfer of at least one good-quality embryo.

You may not qualify if…

• Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
• Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)

Where it is running

• The Chinese University of Hong Kong — Hong Kong, China (enrolling)

Full record on ClinicalTrials.gov

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