A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)
Running, not enrolling · Phase 1 · Has a placebo group
Conditions studied: Healthy
In brief
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time
Key facts
- Study ID
- NCT07388667
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 120
- Starts
- 2026-03-04
- Expected to finish
- 2026-09-09
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- The main inclusion criteria include but are not limited to the following:
- Is in good health
- Has body mass index (BMI) between 25 and 40 kg/m\^2, inclusive. Participants must weigh at least 60 kg
You may not qualify if…
- The main exclusion criteria include but are not limited to the following:
- has a history of previous surgical treatment for obesity (bariatric surgery, gastric banding, etc.) or any other gastrointestinal (GI) surgery that may induce malabsorption, history of bowel resection >20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss (including LAP-BAND®), as well as clinically significant GI disorders (eg, peptic ulcers, severe gastroesophageal reflux disease)
- has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2
Where it is running
- Anaheim Clinical Trials ( Site 0005) — Anaheim, California, United States
- ProSciento Inc. ( Site 0002) — Chula Vista, California, United States
- QPS-MRA, LLC ( Site 0003) — South Miami, Florida, United States
- Bio-Kinetic Clinical Applications, LLD dba QPS-MO ( Site 0004) — Springfield, Missouri, United States
- Hassman Research Institute Marlton Site ( Site 0006) — Marlton, New Jersey, United States
Full record on ClinicalTrials.gov
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