Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
Starting soon
Conditions studied: Anesthesia, Neuroinflammation, Cognitive Disorders
In brief
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors. The study will enroll 160 adult patients (aged 18-65 years) scheduled for elective cholecystectomy surgery, divided into two groups: patients with no previous general anesthesia exposure (n=80) and patients with at least one or more previous general anesthesia exposures (n=80). Serum levels of Brain-Derived Neurotrophic Factor (BDNF), Interleukin-1 beta (IL-1β), and High Mobility Group Box 1 (HMGB1) will be measured using ELISA method at two time points: preoperatively (baseline) and 24 hours postoperatively. Cognitive function will also be assessed at both time points. The primary objective is to evaluate whether multiple exposures to general anesthesia lead to significant differences in serum BDNF, IL-1β, and HMGB1 levels, reflecting changes in neurotrophic balance and neuroinflammatory response. This study aims to provide insights into the potential biochemical mechanisms underlying anesthesia-related cognitive changes and contribute original clinical data to the current literature on general anesthesia safety and neurobiological effects.
Key facts
- Study ID
- NCT07388160
- Run by
- University of Health Sciences Balikesir Hospital Eduation and Research
- People needed
- 160
- Starts
- 2026-01-25
- Expected to finish
- 2026-09-25
- Last updated by the study team
- 2026-02-04
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-65 years
- Scheduled for elective cholecystectomy surgery
- Either no previous general anesthesia exposure OR at least one or more previous general anesthesia exposures
- Ability to provide informed consent
- American Society of Anesthesiologists (ASA) physical status I-II
You may not qualify if…
- Chronic neurological diseases (Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.)
- Psychiatric illness requiring medication
- Metabolic syndrome (diabetes mellitus, hypertension, cardiac disease)
- Chronic inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.)
- Corticosteroid or immunosuppressive therapy within the last 6 months
- Patients requiring intensive care admission
- Pregnancy or breastfeeding
- Known allergy to anesthetic agents
- Inability to provide informed consent
Full record on ClinicalTrials.gov
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