Role of Exercise in PRISm and Subsequent Development of COPD

Recruiting now · Not applicable

Conditions studied: Preserved Ratio Impaired Spirometry (PRISM)

In brief

Preserved Ratio Impaired Spirometry (PRISm) describes individual with spirometry findings of forced expiratory volume (FEV1) and forced vital capacity (FVC) ratio greater than 0.7 but with the FEV1 less than 80% predicted. While the spirometry findings of individuals with PRISm can be transited into obstructive pattern, remains at PRISm or become normal spirometry, limited evidence is on the role of exercise in the course of PRISm. This study aims to investigate the role of exercise, namely exercise with telehealth and walking exercise, together with smoking cessation advice, would alter the clinical course of PRISm.

Key facts

Study ID

NCT07387432

Run by

The University of Hong Kong

People needed

90

Starts

2025-07-14

Expected to finish

2028-01-01

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or above
• Smoker/ ex-smoker
• Spirometry shows PRISm, with FEV1/FVC >= 0.7 and FEV1 <80% predicted
• Ambulatory to walk
• Able to give informed consent

You may not qualify if…

• Age below 18
• Non-smoker
• Spirometry does not show PRISm/ unable to perform spirometry
• Requires assistance for walking
• Unable to give informed consent

Where it is running

• The University of Hong Kong, Queen Mary Hospital — Hong Kong, China (enrolling)

Full record on ClinicalTrials.gov

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