Propofol Infusion and PONV in Cardiac Surgery
Recruiting now
Conditions studied: Postoperative Nausea and Vomiting, Cardiovascular Surgical Procedures
In brief
The aim of this observational cohort study is to evaluate the effect of high-dose versus low-dose propofol infusion on the incidence of postoperative nausea and vomiting (PONV) in patients undergoing coronary artery bypass grafting (CABG). The study also seeks to assess the predictive performance of the Apfel and Koivuranta risk scores for PONV in the cardiac surgery population. The primary objective of this study is to determine the impact of routinely administered high-dose propofol on the incidence and severity of PONV in CABG patients. The secondary objective is to evaluate the need for antiemetic therapy during the intensive care unit stay. The investigators will compare patients receiving high-dose propofol with those receiving low-dose propofol to determine whether the antiemetic effect of propofol is dose-dependent. Participants will be asked to: Allow PONV assessments to be performed during the first 24 hours postoperatively, Provide permission for the collection of clinical data (including demographic characteristics, risk scores, opioid consumption, etc.) for research purposes.
Key facts
- Study ID
- NCT07386379
- Run by
- Istanbul University - Cerrahpasa
- People needed
- 60
- Starts
- 2025-11-01
- Expected to finish
- 2026-04-30
- Last updated by the study team
- 2026-02-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- ASA physical status III
- Elective coronary artery bypass grafting (CABG)
- Surgery performed at Istanbul University-Cerrahpaşa, Cardiology Institute between November 2025 and March 2026
You may not qualify if…
- Gastrointestinal or central nervous system disorders within the past 3 months
- Cochlear disorders associated with nausea and vomiting
- Chronic opioid use
- Advanced hepatic or renal disease
- Alcohol or substance abuse
- Left ventricular ejection fraction < 40%
- Inability to be weaned from mechanical ventilation within 12 hours postoperatively
- Postoperative morphine administration in the intensive care unit
- Combined cardiac procedures (e.g., valve surgery)
- Off-pump surgery
- Emergency surgery
- Reoperation due to bleeding or other complications
- Refusal to participate
Where it is running
- Yasemin Ozsahin — Istanbul, Outside of the US, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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