Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)

Recruiting now

Conditions studied: Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism, Idiopathic Normal Pressure Hydrocephalus (INPH)

In brief

This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related neurological conditions.The purpose of this registry is to collect long-term clinical information from patients with freezing of gait or gait and balance problems, and to explore how different causes of FOG are related to symptoms, walking patterns, falls, disease progression, and outcomes over time. The study will include participants with Parkinson's disease and other conditions associated with freezing of gait.Participants will receive standard medical care as determined by their treating physicians. No experimental drugs or study-related treatments will be assigned as part of this registry. Clinical information will be collected during routine visits and follow-up assessments, including questionnaires, walking and balance evaluations, video recordings, and other commonly used clinical tests.The information collected in this study may help improve the understanding of freezing of gait, support better risk assessment for falls, and guide future research and clinical management strategies for patients with gait and balance disorders.

Key facts

Study ID

NCT07386015

Run by

Tianjin Huanhu Hospital

People needed

700

Starts

2026-02-28

Expected to finish

2030-11-30

Last updated by the study team

2026-03-10

Who can join

Age: 30 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 30-85 years
• Presence of freezing of gait or non-freezing gait or balance impairment
• Diagnosis of Parkinson's disease or related parkinsonian disorders according to established international criteria (including PD, PSP, MSA, DLB, CBD, vascular parkinsonism, or idiopathic normal pressure hydrocephalus)
• Ability to complete gait and balance assessment tasks independently or with assistance
• Ability and willingness to provide written informed consent

You may not qualify if…

• Severe dementia (Mini-Mental State Examination score < 10)
• Severe psychiatric disorders interfering with study participation
• Severe cardiopulmonary, musculoskeletal, or other medical conditions significantly affecting gait safety
• Stroke, fracture, or other major medical events within the past 3 months
• Inability to comply with follow-up procedures
• Refusal of video or speech data collection

Where it is running

• Tianjin Huanhu Hospital — Tianjin, Tianjin Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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