The Effect of Probiotics on Gut Microbiota Changes in Healthy Chinese Adults During Short-Term European Travel: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Healthy Adult

In brief

This study aims to evaluate the efficacy of a probiotic complex (containing Bifidobacterium animalis subsp. lactis B94 and Lacticaseibacillus helveticus R0052) in maintaining gut microbiota homeostasis and supporting physiological and psychological stability among healthy Chinese adults during short-term travel to Europe.

Key facts

Study ID

NCT07384260

Run by

Min-Tze LIONG

People needed

40

Starts

2026-02-01

Expected to finish

2027-01-31

Last updated by the study team

2026-02-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18-65 years, regardless of gender;
• Planning to undertake a short-term round-trip journey to Europe (within 7 days);
• Able to understand and willing to comply with the study protocol, and to cooperate with study procedures;
• Voluntarily sign the informed consent form before any study-related procedures are initiated.

You may not qualify if…

• Diseases that may affect the evaluation of trial results, such as immune dysfunction, severe renal/hepatic dysfunction, severe cardiovascular disease, malignant tumors, acute or chronic infections, etc.;
• Use of probiotic preparations, antibiotics, hormones, immunosuppressants, biological agents, or JAK inhibitors within 4 weeks;
• Subjects with diagnosed or uncontrolled parasitic infections;
• Patients receiving long-term medication for chronic diseases;
• Patients with severe organic lesions in the thyroid, heart, brain, lungs, kidneys, or musculoskeletal system;
• Patients with a history of or currently diagnosed mental illness;
• Patients on long-term corticosteroid therapy;
• Use of growth hormone, γ-aminobutyric acid (GABA), lysine, inositol, or vitamin B12;
• Presence of uncontrolled, clinically significant laboratory abnormalities that may affect data interpretation or subject participation;
• Participation in other clinical intervention studies involving drugs, dietary supplements, probiotics, or prebiotics within the past 4 weeks;
• Presence of severe infections or major trauma deemed by the investigator to potentially affect outcomes, or having undergone moderate to major surgery within the past month;
• Known allergy to any component of the probiotic product;
• Subjects deemed unsuitable for participation by the investigator for any other reason.

Where it is running

• Tsinghua University Science and Technology — Haidian, Beijing Municipality, China
• Universiti Sains Malaysia — Pulau Pinang, Pulau Pinang, Malaysia

Full record on ClinicalTrials.gov

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