Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients

Recruiting now

Conditions studied: Pemphigus Vulgaris (PV), Periodontal Diseases

In brief

The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.

Key facts

Study ID

NCT07384221

Run by

Saglik Bilimleri Universitesi

People needed

20

Starts

2025-11-01

Expected to finish

2026-02-21

Last updated by the study team

2026-02-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 years and older.
• Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
• Presence of at least 10 natural teeth.
• Willingness to participate and signed informed consent.

You may not qualify if…

• Pregnancy or lactation.
• Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
• Periodontal treatment received within the last 6 months.

Where it is running

• University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology — Ankara, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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