High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults
Starting soon · Not applicable
Conditions studied: Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma, Bowen's Disease, BCC, BD
In brief
This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk basal cell carcinomas (BCCs) and Bowen's disease (BD) in adults. The main questions it aims to answer are: * Is HIFU an efficient treatment option for BCCs and BD? * What medical problems do participants get after HIFU? Researchers will compare HIFU to standard cryotherapy with liquid nitrogen to see if the ultrasound works to treat these local and low-risk non-melanosytic skin cancers. Participants will: * Be treated either with HIFU (intervention) or cryotherapy (control). * Visit the clinic 4 weeks, 1-, 3- and 5 years after the treatment for check-ups, tests and survey questions.
Key facts
- Study ID
- NCT07384078
- Run by
- Jussi Salonen
- People needed
- 294
- Starts
- 2026-04-01
- Expected to finish
- 2032-12-31
- Last updated by the study team
- 2026-02-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age 18 years or older at the time of informed consent
- ability to give informed consent and comply with the treatment protocol and follow-up plan
- study lesion located between neck and knees
- one of following histologically confirmed diagnosis: Superficial BCC with maximum diameter of 2.0 cm / Nodular BCC with max. diameter of 1.5 cm / BD with max. diameter of 2.0 cm
You may not qualify if…
- Study lesion location in face, head, genitals, hands, or below the knee
- Clinical/dermoscopical/histological feature for high-risk/aggressive BCC
- Clinical/histological sign for hypertrophic BD
- Clinical/dermoscopical/histological feature for Squamous cell carcinoma
- Gorlin Golz syndrome
- Pregnancy or breastfeeding
Where it is running
- HUS Iho- ja allergiasairaala — Helsinki, Finland
Full record on ClinicalTrials.gov
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