Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia

Starting soon · Not applicable · Has a placebo group

Conditions studied: Anosmia, Inflammatory Anosmia

In brief

This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia. Participants will be randomly assigned to receive either intranasal PRP combined with topical insulin or intranasal PRP alone. Changes in olfactory function will be assessed over time to compare the effectiveness and safety of the two treatments.

Key facts

Study ID

NCT07383415

Run by

Amin Javer

People needed

20

Starts

2026-03-30

Expected to finish

2027-01-01

Last updated by the study team

2026-02-03

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with olfactory dysfunction despite olfactory training therapy
• Loss of smell within the past 5 years
• Loss of smell occurred after an infection
• Platelet count is over 150,000 platelets per microliter

You may not qualify if…

• Have a history of or currently have sinonasal tumours Have a history of surgery or radiotherapy for the base of your skull Have been treated with antibiotics in the past month before surgery Have a condition called systemic vasculitis or any bleeding disorder Have a suspected or known allergy to insulin or PRP or Platelet Lysate (PL) Have inhaled drugs (i.e cocaine) in the past 6 months of your enrollment Smell loss is due to a head trauma or after surgery Unable to complete the Sniffin Stick Smell test or questionnaires

Full record on ClinicalTrials.gov

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