Prospective Cohort Study of Minimal Residual Disease(MRD) Testing for Early Recurrence Detection in Endometrial and Cervical Cancer

Starting soon

Conditions studied: Uterine Neoplasms, Cervical Cancer

In brief

This study aims to evaluate the clinical performance of blood-based Minimal Residual Disease (MRD) testing using circulating tumor DNA (ctDNA) in patients with endometrial and cervical cancer. The researchers will investigate whether MRD detection can identify cancer recurrence earlier than current standard imaging or clinical methods (providing a "lead time"). Participants will undergo blood collection at specific time points, including at diagnosis, after surgery, and during regular follow-up visits. The study will also assess the correlation between MRD status and survival outcomes, such as Relapse-Free Survival (RFS) and Overall Survival (OS). The goal is to establish a foundation for personalized treatment strategies based on molecular monitoring.

Key facts

Study ID

NCT07382505

Run by

Asan Medical Center

People needed

600

Starts

2026-02-15

Expected to finish

2027-12-31

Last updated by the study team

2026-02-02

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed endometrial cancer or cervical cancer.
• Scheduled for or completed standard treatment (Surgery, Adjuvant therapy, or CCRT).
• Provision of written informed consent for study participation and biospecimen collection

You may not qualify if…

• Synchronous other malignancies (cancer requiring treatment within the last 5 years).
• Persistent infection or bleeding tendency that makes repeated blood collection unsafe.
• Inability to follow-up or communicate (e.g., due to geographic or cognitive reasons).
• Any condition that the principal investigator deems inappropriate for the study.

Where it is running

• Asan Medical Center — Seoul, Seoul, South Korea

Full record on ClinicalTrials.gov

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