Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children

Starting soon · Not applicable

Conditions studied: Early Childhood Caries (ECC), Active Dentin Caries in Primary Molars

In brief

Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration. This randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.

Key facts

Study ID

NCT07382245

Run by

October University for Modern Sciences and Arts

People needed

60

Starts

2026-01-30

Expected to finish

2026-03-15

Last updated by the study team

2026-02-02

Who can join

Age: 3 and older, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Apparently healthy children.
• Children with age ranged from 3-5 years from both genders.
• Children who refused dental treatment with Frankl Behavior Rating Scale 1 and 2.
• Children having molars with active dentin caries score (2,3,4) according to International Caries Detection and Assessment System- ICDAS II, detected by visual and tactile.
• Parents/guardians accept treatment and write informed consent.

You may not qualify if…

• Children with allergy to silver from their medical history.
• Children with ulcerative gingivitis.
• Children with primary molars with the following criteria:
• Symptomatic
• Involving the pulp
• Presence of fistula or sinus
• Presence of gingival inflammation and Pain on percussion
• Close to exfoliation

Where it is running

• Faculty of Dentistry, MSA University — Giza, Giza Governorate, Egypt

Full record on ClinicalTrials.gov

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