Biomarkers of Brain Injury in Children With Brain Tumors
Recruiting now
Conditions studied: Brain Tumor, Childhood Cancer, Childhood Brain Tumor
In brief
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is: Can investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors? Researchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers. Participants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.
Key facts
- Study ID
- NCT07381959
- Run by
- Uppsala University
- People needed
- 560
- Starts
- 2021-08-01
- Expected to finish
- 2031-12-31
- Last updated by the study team
- 2026-02-02
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: accepted.
Where it is running
- Uppsala University — Uppsala, Sweden (enrolling)
Full record on ClinicalTrials.gov
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