Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

Recruiting now · Not applicable

Conditions studied: Healthy

In brief

The overall objective of this pilot study is to establish the feasibility and methodological validity of using high-density surface electromyography to characterize motor unit behavior of the quadriceps under thermoneutral and locally cooled conditions, and to generate preliminary data to inform the design of a larger, hypothesis-driven study.

Key facts

Study ID

NCT07381920

Run by

Wake Forest University

People needed

24

Starts

2026-01-20

Expected to finish

2027-05-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women between the ages of 18 and 35 years
• Healthy adults, defined as absence of significant acute/chronic medical condition, injury, and/or illness that may compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study as determined by the Principal Investigator.

You may not qualify if…

• Current diagnosis or history of:
• major metabolic disease (e.g., type I and type II diabetes),
• neuromuscular disease (e.g., cervical spondylotic radiculomyelopathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies),
• cardiovascular disease (e.g., stage II hypertension, heart failure, myocardial infarction/ischemia, peripheral vascular disease, Raynaud's phenomenon, or other conditions associated with impaired peripheral circulation),
• significant myocardial or pericardial diseases (e.g. amyloidosis, constriction),
• moderate or severe valvular disease,
• pulmonary/respiratory disease (e.g., asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease),
• cancer,
• renal disease,
• liver disease,
• or anemia.
• Current or recent musculoskeletal injury (e.g. fracture, sprain, dislocation) or any physical disability that precludes safe and adequate testing.
• Pregnancy or breastfeeding.
• Thigh circumference greater than 23 inches
• Mid-thigh skinfold thickness greater 40 mm

Where it is running

• Department of Health and Exercise Science at Wake Forest University — Winston-Salem, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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